I've read that unheated honey contains "enzymes" (or something enzyme-like) in the form of carbohydrate structures, which can disassemble pretty much anything you eat; even bones. They're allegedly destroyed above 100°F with some damage occurring at temperatures as low as 93°F. Bees flap their wings to cool down their honey and hives when it gets too hot, and what I've read is that they tend to cool them down to 93°F or less. I've also read that eating unheated honey accelerates healing.
I'm very distrustful of "established" science, particularly when it comes to health, but in spite of that I decided to briefly look for answers to questions I had about these claims.
The mainstream view is that the only true enzymes in unheated honey are serine proteases, which take apart proteins, but honey's serine proteases are much less active than something like the cysteine proteases in pineapples and kiwifruit. They say carbohydrate structures which act like enzymes don't exist; however, they say there are glycoproteins and enzyme cofactors in unheated honey that can enhance the activity of enzymes in their vicinity. This could be the key to it all. You and your microbes produce tons of enzymes in your digestive tract (and elsewhere), which may have their activity enhanced by the glycoproteins and enzyme cofactors. It's also worth mentioning that raw foods contain digestive enzymes, as they haven't been destroyed by heat. Raw foods digest better than cooked foods except in the case of plants, but unheated honey may even be able to enhance raw plant digestion. Glycoproteins and enzymes can both be fragile enough to be destroyed at relatively low temperatures like 100°F too. This explanation also fits into the idea that eating unheated honey accelerates healing. Enzymes are one of a few ways that your body can dissolve dead cells before replacing them with new cells. Through improved digestion, you also get more nutrients for creating and maintaining cells. For now, these glycoproteins and enzyme cofactors are my accepted explanation for the claims at the top of this post.