Does it count if the option is clearly a joke? A bunch of Acquire games let you get early game overs by picking totally irrational dialog options.
>Way of the Samurai lets you tell a gang member harrassing a girl to let you in on his gang rape (when he's actually genuinely in love with her and trying, but failing, to win her over), and he's so disgusted he and his goons tie you to the railroad tracks in response
>Akiba's Trip 1 lets you perv on your interrogator mindlessly till the organization interrogating you doesn't consider your character worth recruiting and lets you fry in the sun
>Akiba's Trip 2 starts with the player captured after falling for a rather obvious scam seller offering rare anime figures. If you keep demanding the figurines as you're tied up and about to be turned into a monster your captor will conclude you're totally whacko and start the process to make you a monster before you get saved
The other Way of the Samurai games have some options to just totally ignore or chase away the opening vignette (guy finds you wounded and wants to help? Draw your sword on him!), but these actually have a point to them for playthroughs you just want to do non-story content (the series is NG+ focused, so devoting a playthrough purely to doing side quests so you can afford to improve your sword more is an entirely valid choice)
Aside from that, there's selling the PDAs to Owl in
Call of Pripyat. This locks off several quest lines and the official "neutral" bonus is actually obtained by selling half the PDAs to one faction and half to the other rather than selling any to the neutral Owl. The money Owl offers is also so low as to be pointless. This option exists purely as a trap for the sake of it.
>>985742
There's also the fact that the Geth, via their official ambassador, have outright told the player they'd rather die than merge with the Reapers. It can't even justify itself by how it "saves" the Geth because it goes against their explicit wishes.